Download e-book for iPad: Cell-Penetrating Peptides: Processes and Applications by Ulo Langel

By Ulo Langel

one of many significant issues of drug supply is the lack of huge hydrophilic compounds to go through the lipid membrane of the phone, hence making medications equivalent to polypeptides and oligonucleotides of restricted healing worth. until eventually lately, the shipping of such molecules into the cytoplasmic and nuclear cubicles of dwelling cells appeared a distant target. therefore, the invention that peptides derived from the HIV Tat protein and homeodomain of the Antennapedia transcription issue (penetratin) can translocate around the plasma membrane of dwell cells has unfolded fascinating new probabilities in biomedical research.

This booklet fills the necessity for a finished replace of the learn bearing on those really expert peptides, referred to as cell-penetrating peptides (CPPs), to which the drug molecule can connect and go through the cellphone membrane. Divided into 3 components, Cell-Penetrating Peptides: strategies and functions covers sessions of cell-penetrating peptides; mechanisms of mobile penetration, interactions of cell-penetrating peptides with plasma membranes, and lipid types; and functions of cell-penetrating peptides. those divisions conceal all info from simple biochemistry to scientific software, together with a transparent description of the final ideas for mobile uptake of the delivery peptides. The evaluate of labor during this quarter will bring about larger designed novel delivery peptides to accomplish the extra winning software of CPPs in examine and therapy.

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Cell-Penetrating Peptides: Processes and Applications (Pharmacology and Toxicology: Basic and Clinical Aspects) by Ulo Langel

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